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Articles

Vol. 2 No. 6 (2025)

Novel Biomarkers of Beta-Cell Stress in Early Type 2 Diabetes

Submitted
January 22, 2025
Published
2025-02-15

Abstract

Identifying biomarkers of beta-cell stress may enable earlier intervention in type 2 diabetes. In a prospective cohort of adults with new-onset disease, the circulating proinsulin-to-C-peptide ratio and urocortin-3 (UCN3) peptide levels predicted rapid glycemic progression independent of HbA1c and BMI. Adding these markers to clinical models improved risk reclassification and calibration. External validation in larger, multiethnic cohorts is warranted before clinical adoption.