GLP-1 Receptor Agonists and Weight Regain after Discontinuation: A Multicenter Cohort

Abstract

Discontinuation of GLP-1 receptor agonist therapy often leads to partial weight regain. In a multicenter cohort of adults with obesity and diabetes, approximately two-thirds of prior weight loss was sustained at 12 months, particularly among individuals who adopted structured diet and activity programs. Early transition to alternative pharmacotherapy mitigated regain in high-risk groups. These data can inform deprescribing strategies and patient counseling.