Transmission of Dysbiotic Maternal Microbiota in Gestational Diabetes to Newborns

Abstract

Gestational diabetes mellitus is increasingly recognized as a determinant of infant gut health. Evidence indicates that mothers with GDM transfer dysbiotic microbial communities characterized by low diversity and higher abundance of opportunistic taxa to neonates. Such vertical transmission contributes to early-life metabolic susceptibility. Mechanisms include altered maternal inflammation, placental signaling, and delivery mode factors. Preventive interventions such as probiotics, maternal diet optimization, and intrapartum antibiotic stewardship may reduce infant microbiome disruption.